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Hepatic biotransformation of MLN8054 was studied in vitro employing human liver S9 fractions (Details on file, Millennium). Glucuronidation of your carboxylate moiety of MLN8054 to an acyl glucuronide was the predominant mechanism of biotransformation, Hydroxylation with the azepine moiety of MLN8054 was the most important period one biotransformat

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